Jump-Starting Your Library Research Online

Jump-starting kinesin

When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin discriminates among its many potential cargo molec...

Cortical function: Jump-starting the brain

Magnetic stimulation as used in studies of the human brain may not merely disrupt cognitive functions, but also enhance them. The direction of the effect may depend on the frequency of stimulation as much as the area of the brain that is stimulated.

Jump-starting tumor-specific T cells

Vaccination with tumor antigens causes tumor regression in some melanoma patients despite negligible expansion of vaccine-specific T cells. Vaccination may instead result in the expansion of T cells specific for tumor antigens not contained in the vaccine, thus facilitating tumor regression, according to two articles from Pierre Coulie and colleagues on pages 241 and 249. Tumor-specific T cells...

Starting a Telecommunications Plan in Your Community

2 Broadband refers to the transmission via telecommunications of a large volume of data. For example, the FCC (2000) defines advanced telecommunications capability as “infrastructure capable of delivering a speed of 200 kilobits per second (Kbps) in each direction,” while the Commission denominates as “‘high-speed’ those services with over 200 Kbps capability in at least one direction.” Plannin...

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